Residential context is important to older adults’ health. Numerous studies have linked adverse residential conditions, such as physical disorder, to poorer functional status, chronic health conditions, and cognitive decline. A growing literature investigating possible physiologic pathways between residential contexts and health has focused on biological markers. As indicators of normal biological processes, biomarkers may reflect aging-related health and functional changes and have been linked to morbidity and mortality. For example, inflammatory markers, such as C-reactive protein (CRP) and interleukin-6 (IL-6), are associated with physical function decline, cardiovascular disease, and mortality in older adults, but the underlying biologic mechanisms remain understudied. Thus, examining the relationships between adverse street block conditions and biomarkers of aging would further an understanding of the physiological mechanisms through which residential context influences aging and health. A study described in the November 2021 issue of the Journals of Gerontology Series A: Biological Sciences and Medical Sciences was to test associations between adverse street block conditions and biomarkers of aging among a nationally representative cohort of US adults aged 67 years and older.
The investigators posit that smaller area units should be considered because older adults’ life space can decrease with the onset of age-related health or functional limitations. Conditions of the residential environment proximate to the home, such as the street block on which the home is situated, may be more influential in older adults’ everyday lives than the wider neighborhood context. They hypothesized that the presence of any street block disorder is associated with higher levels of four biomarkers of aging: hemoglobin A1C, high-sensitivity CRP, IL-6, and CMV antibodies. They found that participants living on disordered blocks were more likely to be Black or Hispanic than White, have a high school education or less, and have a lower average income to poverty ratio compared to participants living on blocks with no disorder. These participants also were more likely to experience financial strain, be unmarried, rent their home, have a larger mean household size, live in a non-single-family type home, have had less than average family wealth growing up, and have been born outside the United States.